England return to action on Saturday evening at Wembley Stadium with one of the toughest assignments in international football. The Nations League opener pitches Thomas Tuchel's side against Spain, the newly crowned world champions, in the first meeting between the teams since the summer's World Cup.

Kick-off for the Nations League opener is set for 7:45 p.m. BST in London, which is 2:45 p.m. ET in the United States. It is England's first match since finishing third at the 2026 World Cup, and Spain's first competitive game since lifting the trophy.

A rematch of the Euro 2024 final

These two sides have plenty of recent history. Spain beat England 2-1 in the Euro 2024 final in Berlin, with goals from Nico Williams and Mikel Oyarzabal, and they have taken six of the last nine meetings between the teams. Across 28 meetings in total, England have 13 wins, Spain have 11, and four games have finished level.

This summer added another chapter for both teams. Spain won the 2026 World Cup after beating Argentina 1-0 in the final, with Ferran Torres scoring the winner in the second half of extra time. England, meanwhile, lost their semifinal to Argentina before beating France 6-4 in one of the most chaotic third-place matches the tournament has seen. The Nations League opener will show how quickly either side has moved on from those highs and lows.

England are back in League A after winning their League B group in the previous edition of the competition. They sit in Group 3 alongside Spain, Croatia and Czechia. The top two teams in each League A group advance to the quarter-finals in March 2027, so a result in the Nations League opener carries real weight from the very start.

Injuries force England changes

Tuchel's preparations for the Nations League opener were hit by injuries, with Declan Rice, Cole Palmer, Marcus Rashford, Kobbie Mainoo and Tino Livramento all withdrawing from the squad. Morgan Gibbs-White and James Garner were called up as replacements, as reported by Enigma Football, and young players including goalkeeper James Trafford have a chance to stake a claim.

The expected England lineup still has plenty of quality. Harry Kane and Jude Bellingham remain the focal points of the attack, supported by Bukayo Saka and Anthony Gordon, while the midfield will be built around Elliot Anderson and Myles Lewis-Skelly. Kane recently became the fastest player to reach 100 Bundesliga goals, and Bellingham has scored five goals in three of his last four appearances for England.

Spain travel to London with the squad that won the World Cup, led by Golden Ball winner Rodri. Lamine Yamal has seven La Liga goals this season, and Ferran Torres arrives in form after scoring a Champions League hat-trick for Paris Saint-Germain. according to USA Today that the visitors are unbeaten in 38 matches in normal time, a run that makes the size of England's task in the Nations League opener very clear.

What both managers said

Speaking before the game, Tuchel described the Nations League opener as a new beginning for England and said the team wanted to close the gap on Spain. He called Spain's defending as impressive as their attack, adding that his side had a plan and the ambition to be the exception to the rule.

Spain manager Luis de la Fuente struck a similar note from the other side. He said one story was over and another had begun, insisting that the world champions could not rely on what they achieved in the summer and wanted to keep doing important things against a major opponent.

The fixture is also England's opening match of a demanding international window that continues with games against Czechia and Croatia. Tuchel has identified reaching the last four of the Nations League as the team's objective, which makes the Nations League opener an early test of whether England can compete with the best teams in Europe.

How to watch the Nations League opener

The game is being shown on FS2 in the United States, while viewers in the UK can watch on ITV1 and ITVX. Wembley is expected to be close to full for the occasion, with England supporters keen to see how the new-look squad measures up against the world champions.

For Spain, the Nations League opener is about starting a new cycle in the right way. For England, it is about proving that the gap to the champions is smaller than the Euro 2024 final suggested. One way or another, the Nations League opener should set the tone for Group 3, with both teams knowing that every point matters on the road to the March quarter-finals.