Stockholm opens one of science's favorite guessing games on Tuesday morning, when the Royal Swedish Academy of Sciences announces this year's physics laureates. The Nobel physics prize announcement is set for 11:45 a.m. Stockholm time, which means most American readers will wake up to the news. It arrives one day after the medicine prize opened this year's award season with a trio honored for optogenetics, and it keeps the spotlight on the question that dominates physics departments every autumn: which discovery finally gets the call.

A day earlier, Karl Deisseroth of Stanford, Peter Hegemann of Humboldt University in Berlin, and Georg Nagel of the University of WΓΌrzburg shared the medicine prize for discoveries behind optogenetics, a technique that uses a light-sensitive protein to switch individual nerve cells on and off in a living brain. The method, which the award-giving body said is now used in laboratories around the world to decode the brain's mysteries, grew from the unlikely starting point of a single-celled alga that swims toward light, according to reporting by Reuters.

The most recent Nobel physics prize announcement honored John Clarke, Michel Devoret, and John Martinis for experiments that showed quantum tunneling playing out on a macroscopic scale. Conducted four decades ago at the University of California, Berkeley, the work used an electrical circuit built from superconductors to reveal that a system of countless charged particles could behave as a single quantum object. The committee said the discovery laid groundwork for a new generation of powerful computers, according to reporting by the BBC.

What the Nobel physics prize announcement could crown

Physics World, the magazine of the Institute of Physics, has tracked Nobel physics trends with an infographic updated over a decade, and its editors argue that condensed-matter physics is overdue for a win. Their case leans on Clarivate's annual citation laureates list, which forecasts winners from the most heavily cited research. This year's physics shortlist from the analytics firm sits entirely in condensed matter: Chihaya Adachi, Stephen Forrest, and Mark Thompson for work leading to ultrahigh-efficiency organic light-emitting diodes; Nicola Spaldin for theoretical work on room-temperature magnetoelectric multiferroics that Clarivate says could enable new energy-efficient devices; and Qikun Xue for the experimental observation of the quantum anomalous Hall effect.

Other prestigious prizes point the same way. The 2026 Kavli Prize in Nanoscience went to Eva Andrei, Pablo Jarillo-Herrero, and Allan MacDonald for twistronics, the field of twisting two sheets of two-dimensional material such as graphene to create moire superlattices with properties including superconductivity. Meanwhile, Federico Capasso of Harvard, who developed the quantum cascade laser and did pioneering work on optical metamaterials, remains a perennial candidate, with possible partners including Imperial College's John Pendry and Duke's David Smith, according to Physics World.

The long shots: antimatter and the mathematics of waves

Particle and nuclear physics is also considered due by the infographic's logic, though Physics World concedes the candidates are thinner. One possibility for this year's Nobel physics prize announcement is the CERN teams behind the ATHENA and ALPHA collaborations, which trapped cold antihydrogen atoms and compared their properties against hydrogen in search of clues to why the universe holds so much more matter than antimatter. Denmark-based physicist Jeffrey Hangst, a founder of both collaborations, would be a likely name, but the experiments have yet to find significant deviations from the Standard Model, which could delay the honor.

A more mathematical long shot comes from wavelet theory. Clarivate's earlier forecasting proposed Ingrid Daubechies, Stephane Mallat, and Yves Meyer for advancing wavelet theory, described as a revolution in mathematics and physics with practical applications from image processing to signal compression. As Physics World notes, it would be difficult to fit such an award into a traditional physics category, but the committee has surprised forecasters before.

The announcement streams live on the Nobel Prize's official channels, and the physics laureates share a prize sum of 12 million Swedish crowns, roughly $1.2 million, with medals and diplomas presented in Stockholm in December. The committee's choice often shapes which research lines win funding and which labs attract graduate students, so the Nobel physics prize announcement matters well beyond the ceremony.